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50k Damage
According to the equation for the damage calculations of Heat Buster...
50,000 = Base Damage * [1 + 3*(Alchemy Mastery Bonus + Fire Alchemy Bonus)]
Base damage at Rank 1 = 1175 (assuming max)
50,000 = 1175 * [1 + 3*(Alchemy Mastery Bonus + Fire Alchemy Bonus)]
50,000 / 1175 = 42.5531914893617
42.5531914893617 = 1 + 3*(Alchemy Mastery Bonus + Fire Alchemy Bonus)
41.5531914893617 = 3*(Alchemy Mastery Bonus + Fire Alchemy Bonus)
42.5531914893617 / 3 = 14.18439716312057
14.18439716312057 = (Alchemy Mastery Bonus + Fire Alchemy Bonus)
In order to do 50,000 damage with Heat Buster, it seems you need around 14 points of Alchemy Mastery and Fire Alchemy bonus.
This is all a guess. Do not expect me to be right. :l