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50k Damage
According to the equation for the damage calculations of Heat Buster... Now with Critical Hit!
50,000 = 1.5 * Base Damage * [1 + 3*(Alchemy Mastery Bonus + Fire Alchemy Bonus)]
Base damage at Rank 1 = 1175 (assuming max)
50,000 = 1.5 * 1175 * [1 + 3*(Alchemy Mastery Bonus + Fire Alchemy Bonus)]
50,000 = 1762.5 * [1 + 3*(Alchemy Mastery Bonus + Fire Alchemy Bonus)]
50,000 / 1762.5 = 28.36879432624113
28.36879432624113 = 1 + 3*(Alchemy Mastery Bonus + Fire Alchemy Bonus)
27.36879432624113 = 3*(Alchemy Mastery Bonus + Fire Alchemy Bonus)
27.36879432624113 / 3 = 9.122931442080377
9.122931442080377 = (Alchemy Mastery Bonus + Fire Alchemy Bonus)
In order to do 50,000 damage with Heat Buster, it seems you need around 10 points of Alchemy Mastery and Fire Alchemy bonus.
This is all a guess. Do not expect me to be right. :l
Too lazy to edit previous text.