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Alchemy Damage Reduction
Fragment of a discussion from Talk:Guard Cylinder Mastery
It's basically a penalty so players are persuaded to use Cylinder + Guard Cylinder combo rather than Weapon + Guard Cylinder.
Players using C+GC will receive full damage damage when using alchemy, but less melee damage.
Players using W+GC will receive a "damage penalty", but do more/less melee damage depending on the dualed weapon.